Computational Biologist I/II - Arima Genomics : Job Details

Arima Genomics is a San Diego-based startup which is revolutionizing the way Genomic Data is used in basic and disease research. We believe that the state of the art of genomics research, in its 1-Dimensional context, misses the bigger picture, and our technology for capturing chromosome structure will enable a higher dimension of insight into mechanisms of human disease.

Just like our technology is on another level, so are our employees. Our employees are self-reflective and accountable self-starters that are tenacious and relentless in the pursuit of excellent scientific products. They dont have jobs, they have passion projects!

Our environment is open and collaborative and we invest in each others growth and empower one another. We listen to and value differences in perspective and approach.

As a startup, we move fast, adapt to change and are continuously improving ourselves, our processes and our products. Though we are adaptable we constantly prioritize to stay focused on our vision.

What we are looking for?

Is your passion creating algorithms to extract novel insights from genomics data that disrupt conventional thinking and approaches?

If so, then please apply for this position by submitting your resume and a concise cover letter about how your algorithms have challenged the status quo.

And if not, then please check out one of the other great positions Arima has open.

How will you make an impact?

The Product Development team is seeking a Computational Biologist I that will drive innovation through new methods to derive actionable insights from chromosome conformation data. The ideal candidate will be able to leverage a suite of Machine Learning or other tools to build highly accurate classifiers from chromosome conformation and other genomic data for translational applications.

This position requires a self-starter who thrives in a fast-paced working environment, and possesses a well-rounded genomics skill set to design and execute thoughtful Analysis, extract meaningful interpretations, and communicate results and propose future directions to peers and management. This work will be in the context of growing Arimas bioinformatics tools and Democratizing chromosome structure analysis. This position will interface with Scientific Affairs, Marketing, Product Management, Assay Development, and Tech support and is ideal for someone who has a demonstrated ability to wear multiple hats

What you will do:

Participate in manual review of HiC Variant calls.

Create user friendly pipelines geared toward customer enablement.

Support Assay Team with primary and ad hoc analysis

Implement visualization to intuitively represent spatial genomics data and to streamline publication.

Create and implement bioinformatic QC metrics with appropriate thresholds to aid in quality management.

Benchmark tools and algorithms to determine the most accurate methods for analyzing data.

Understand how bioinformatics complements genomics assays and be able to use this knowledge to provide feedback for assay development.

Algorithm development to create novel analysis tools for HiC and HiC related data and their integration with other genomics data types.

Contribute to the design and planning of computational products and timelines

Present interpreted results and proposals of next steps to management.

Collaborate effectively with peers, cross-functional teams and mangers across the organization.

Stay well-informed on current technology trends and scientific literature related to your specific project, as well as the broad application areas of Arimas products and services.

Anticipate project challenges early, work to resolve them, and utilize good judgement when raising challenges to management.

Participate in R&D lab meetings, fostering an environment of intellectual curiosity and critical thinking, while maintaining an awareness for technology commercialization and product development

Contribute analysis, and writing for research proposals, patent applications, SOPs, user guides, and technical notes as necessary.

Assist in technology transfer and training between Product Development and other internal departments

Participate in additional special team or individual projects.

What we are looking for:

Strong working knowledge of a variety of genomics Data including HiC data.

Hands-on experience and proven proficiencies working with bioinformatics analysis of NGS data - the ability to both understand and use existing bioinformatics tools, as well as write custom data analysis and data visualization programs.

Proficiency in at least one programming language such as Python, C, C++, R, or other.

Experience with version control with Git.

Background in algorithms and experience developing classification algorithms using genomics data.

Experience training and validating machine learning or deep learning models is a plus.

Demonstrated ability to drive research projects in a team environment.

Excellent written and verbal technical communication skills.

Demonstrated leadership, initiative, organizational skills, and inter-personal communication abilities.

Ph.D. with 0-1 year of Industry experience or Masters degree with 2 years industry or a Bachlers degree with 5 years of industry experience in Bioinformatics, Computational Biology or other related scientific field.

Arima Genomics believes that everyone has the ability to contribute to company success, and we are committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information.