Director - ADME Project Leadership - Eli Lilly : Job Details
Director - ADME Project Leadership
Eli LillyJob Location : Indianapolis,IN, USA
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. Lilly's Drug Metabolism and Pharmacokinetics (DMPK) team is seeking an experienced pharmaceutical scientist to lead ADME (absorption, distribution, metabolism, excretion) science efforts. You will work on cross-functional teams to advance our portfolio. Our diverse group uses in vitro, in vivo, and in silico methods to study pharmacokinetics, absorption, and disposition of new chemical entities. As a technical leader, you'll contribute within the department and across teams. This role involves experimental design and data interpretation to drive the discovery and development of investigational targets and new therapies. We are passionate about making an impact in the lives of our patients. Consider joining our efforts by applying to Lilly today! Responsibilities:
- Accountable for the delivery of scientifically integrated data packages to guide compound selection, study design, portfolio decisions, and regulatory submissions.
- Collaborate with cross-functional teams in Discovery and Development, including Toxicology, Pharmacology, Chemistry, Clinical PK/PD, Clinical Pharmacology, Regulatory, and Medical. Your goal will be to assess drugability, optimize ADME properties, and advance drug candidates to the clinic. You'll also design and support nonclinical and clinical studies, contributing to global registration packages.
- Lead R&D initiatives to grow and develop ADME/DMPK capabilities across experimental and drug modalities.
- Integrate in vitro, in vivo, and in silico ADME data with Biology and Chemistry insights to define structure-activity and structure-property relationships. Develop strategies for favorable molecular and experimental design.
- Prepare data packages to support global regulatory submissions and correspondence as well as represent ADME in face-to-face discussions with regulators.
- Guide junior, peer, and upper level scientists in best and modern practices of multi-property optimization through the use of mechanistic ADME principles.
- Effectively partner to apply innovative PBPK approaches to translate and predict human PK, inform clinical plans and support registration.
- Communicate the value of mechanistic ADME approaches both internally within R&D and externally including regulatory agencies.
- Build a strong external network (e.g. academia, consortia) and keep up to date with emerging literature and science in the area.
- Experience in drug discovery and development across a variety of therapeutic areas.
- Experience with molecular modalities beyond small molecules (biologics, peptides, oligonucleotides).
- Detailed understanding of pharmacokinetics, ADME and proficiency to communicate theory and concepts clearly.
- Ability to balance multiple projects and handle competing responsibilities.
- Experience with modeling software (e.g. SimCYP, GastroPlus, NONMEM, Matlab etc.).
- Demonstrate strong communication skills with the ability to integrate diverse perspectives, adroitly deliver critical messaging, and influence leaders/key partners.
- Collaborative team behaviors and aspiration to build and sustain relationships with R&D customers and the wider scientific community.