Peptide Synthesis and Purification Research Associate - Stealth Mode Biotech : Job Details

This Stealth Mode Company is a top-tier venture backed, privately held biotechnology company on a mission to create a new modality to end all modalities . The team is aspiring to drastically scale up and change the trajectory of drug discovery by tackling the biggest challenges of existing modalities, and applying the platform to targets with the highest impact for patients. The Company is co-founded by a seasoned entrepreneur with a track record of establishing successful biotech ventures, both public and private, alongside another co-founder who formerly served as President of R&D for a large pharmaceutical company.

We are seeking a senior research associate for our Cambridge site with expertise in peptide synthesis and purification to support the chemistry platform.

Responsibilities

• Program, operate and troubleshoot automated parallel peptide synthesizers.
• Design and synthesize novel peptides to support drug discovery programs.
• Program and operate analytical LC-MS and preparative HPLC instruments to purify polypeptides and confirm their structure.
• Develop protocols and methodologies for the synthesis, analysis, and purification of synthetic peptides.
• Diligently record and analyze experimental plans and complex data sets.

Required Qualifications

• BA/BS or MSc degree in chemistry or biochemistry
• Experience in organic synthesis including solid-phase peptide synthesis (SPPS)
• Knowledge and appreciation of laboratory safety procedures.
• The successful candidate should be self-motivated, enjoy working in a fast-paced dynamic team environment, and be inspired to develop and apply new technologies to advance projects efficiently.
• Excellent written, organizational and documentation skills. Ability to communicate progress effectively with colleagues across several scientific disciplines and managers.

Preferred Qualifications

• 3+ years of research experience in the synthesis, purification and QC of a wide range of peptides containing standard and nonstandard amino acids.
• Experience in the synthesis and analysis of peptide libraries.
• Experience in advanced analytical techniques such as NMR, UV-VIS, FTIR
• Experience in LC-MS analysis and HPLC purification of peptides