Principal Scientist - In Vivo Pharmacology Lead-Seattle Metro Area - Pfizer : Job Details

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Locations: United States - Washington – Bothell

Time Type: Full time

Posted on: 26 Days Ago

Job Requisition ID: 4917965

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy, or supporting clinical trials, you will apply cutting-edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.

This position is based at our Bothell, WA site which is approximately 15 miles from the downtown Seattle area. You will participate in pre-clinical drug discovery and development projects with a focus on ADC Biology and Cancer Immunology. You will be responsible for working with project teams to design, plan, and execute an in vivo strategy to ensure efficient and effective decision-making. You will also be a key stakeholder/contributor to the In Vivo Committee, responsible for vetting study designs and strategies and ensuring timely completion of research project objectives. You will directly supervise laboratory staff that make up an in vivo team responsible for study execution and data analysis, in addition to playing a role in the In Vivo Pharmacology department strategy. You will provide technical and scientific expertise in in vivo pharmacology across the Oncology Research Unit (ORU) to enable target identification, validation, prioritization, and efficient drug discovery.

• Collaborate across project teams to establish in vivo strategy and study plans for drug discovery projects.
• Serve as the in vivo pharmacology lead for several drug discovery projects. Ensure that projects have all critical in vivo data to enable project stage dependent decisions.
• Work within multi-functional teams to support target identification, validation, drug discovery, and combination therapy.
• Work across in vivo teams in a highly collaborative manner, sharing expertise and resources to meet study needs across In Vivo Pharmacology.
• Design and conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification, and analysis.
• Supervise and guide a small team of scientists.
• Develop and characterize new in vivo mouse models, including cell-line derived xenografts, syngeneic tumor, and genetically engineered mouse (GEM) models, to study biologic mechanisms and support exploration of novel cancer immune therapeutics and targeted therapies.
• Ensure team members comply with all regulatory requirements and internal policies.
• Facilitate and lead the development and execution of ancillary in vitro assays necessary to maximize the contribution by the in vivo team, if necessary.
• Interpret, present, and document experiments as well as prepare reports. Written and verbal presentation of results within a multidisciplinary team environment.
• Contribute to relevant in vivo sections of study reports and regulatory documents e.g., IND filings.
• Publish results in scientific peer-reviewed journals and present at internal, national, and international meetings.

Must-Have

• Ph.D. in Cancer Biology, Immunology, Genetics or a related discipline and a minimum of 5 years of industry experience including technical and scientific experience in drug discovery and preclinical development OR
• MS in Cancer Biology, Immunology, Genetics or a related discipline and a minimum of 10 years of industry experience including technical and scientific experience in drug discovery and preclinical development OR
• BS in Cancer Biology, Immunology, Genetics or a related discipline and a minimum of 13 years of industry experience including technical and scientific experience in drug discovery and preclinical development.
• Experience in collaborative research in Oncology drug discovery programs.
• Experience with animal models of human cancers.
• Hands-on in vivo (e.g., IV, PO dosing, blood/tissue collection) and ex vivo skills (e.g., flow cytometry, western blot, ELISA).
• Experience supervising a small team of Scientists.
• Excellent written and oral communication and presentation skills.
• Proficiency with all common office and scientific software.

Preferred

• Strong track record of publications or evidence of equivalent achievements in industry.
• Experience with GEMM and humanized models.
• Experience with Antibody Drug Conjugates (ADC).

Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations, and ability to perform complex data analysis.

Must be willing to work after hours as needed to ensure study integrity.

The annual base salary for this position ranges from $99,900.00 to $166,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share-based long-term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits including medical, prescription drug, dental, and vision coverage.

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.