Process Development Engineering Senior Scientific Associate - Vertex Pharmaceuticals Incorporated : Job Details

Job Description

Vertex has established a new research site in Boston Seaport where research, development, and clinical manufacturing for cell and genetic therapies will be primarily based. Cell and genetic therapies represent two rapidly emerging therapeutic modalities with the potential to treat—and even cure—several of the diseases Vertex is focused on, including sickle cell disease, Duchenne muscular dystrophy, and type 1 diabetes. Further investment in a research site specifically designed to advance these programs will be key to Vertex's continued and sustained leadership in these exciting approaches. At Vertex Cell and Genetic Therapies (VCGT), our teams bring together the best biology, technologies, and enhanced manufacturing capabilities to ensure we bring these cutting-edge transformative therapies to patients as quickly as possible.Vertex is seeking a talented Process Development Engineering Senior Scientific Associate to join our Process Development team. This individual will support the media development projects in cell and gene therapy applications, through a combined approach of fundamental hypotheses and high throughput screening and optimization.

Key Duties and Responsibilities:

• Design and perform experiments and data analysis on media development and optimization.
• Coordinate studies and new assays needed with analytical development.
• Collaborate with cross-functional stakeholders including Research and Manufacturing Science teams, to support the implementation of innovations in cell culture media to the commercial scale manufacturing.
• Utilize fundamental understanding of molecular and cell biology to guide the experimental design and focus on media development.
• Apply statistical principles and DoE approaches to guide process optimization.
• Collaborate with team members, align on project goals and priorities, share results, and participate in team discussions.
• Contribute to fostering a collaborative working environment and positive team culture.
• Ensure data integrity by timely completion of phase-appropriate documentation, including experiment recording in electronic notebook system, develop protocols, and author reports to support future technology transfer and regulatory filings.
• Ensure compliance with lab safety procedures.
• Periodic weekend work required.

Required Qualifications:

• A Master's degree in Biochemistry, Engineering, Biology, or related discipline and 0-2 years of experience, or a BS degree and 4+ years of experience, or the equivalent combination of education and experience.
• Process development experience in a bio-pharmaceutical setting working with interdisciplinary and cross-cultural teams.
• Experience in aseptic processing and cell culture.
• Ability to effectively communicate findings, progress, and problems.
• Ability to collaborate and work effectively in a multidisciplinary team.
• Strong organizational skills and high attention to detail.
• Experience in cell therapy.
• Experience in media development and optimization.
• Pluripotent stem cell culture experience in 2D and/or 3D.
• Experience performing stem cell differentiation.
• Experience working with bioreactors and high throughput cell culture platforms.

Flex Designation: On-Site Designated

Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Company Information:

Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.