Production Chemist - ION Biosciences : Job Details

Production Chemist

About ION

ION Biosciences is a biotechnology company based in San Marcos, Texas. We are focused on the development and use of leading-edge fluorescent assay technologies to accelerate drug discovery research. Our product portfolio includes fluorescent ion indicators and cell health/cell metabolism reagents and kits to measure cell activities in response to compounds such as drugs or other extracellular cues.

Position Summary

ION Biosciences is offering a full-time position to join our Chemistry Production team in San Marcos, Texas. This role requires a strong background in organic synthesis techniques, working to synthesize or purify intermediates and final products in gram-scale quantities. This position reports to the Production Manager.

Responsibilities

• Follow lab safety practices, wear appropriate PPE, maintain a clean work space and meticulously document experiments and results in e-lab notebook.

• Multi-step synthesis of gram scale products and intermediates for fluorescent ion indicators, following described experimental procedures and known synthetic routes.

• Conducting separation techniques including distillation, crystallization, filtration and extraction (including liquid-liquid).

• Performing purification techniques, mainly traditional column chromatography, recrystallization, preparative TLC and preparative LC.

• Work with standard equipment such as glass columns, round-bottomed flasks, hot plate/stirrers, rotary evaporators, vacuum pumps, lyophilizers, fume hoods and other standard laboratory glassware and equipment.

• Drafting documents formalizing your knowledge, procedures and results using basic terms and common computer skills.

Qualifications

• Bachelor's of Science in Chemistry; focus in Organic Chemistry is preferred. PhDs will not be considered.

• 2+ years of experience in a synthetic chemistry production role, producing gram scale or greater quantities is preferred. Interviews will focus on synthetic chemistry skills.

• Familiarity with standard chemical reactions and work-up skills is required. Monitoring reactions by TLC, developing mobile phases, refluxing, temperature control, drop-wise addition and inert atmospheres should all be second nature to the appropriate applicant.

• Knowledge of common synthetic reactions like reductions, acetylations, esterifications, alkylations, couplings, hydrolysis, etc., is required.

• Proficiency with Microsoft Office Suite, Google Drive applications and ChemDraw are a plus.

• An ideal candidate has a working proficiency with liquid chromatographs such as an HPLC, LCMS or prepLC.

Requirements

• Daily duties are performed in an office and laboratory setting.

• Minimum of 40 hours per week.

• May require lifting or moving items weighing up to 25 lbs.