Scientist, Nucleic Acid Delivery + In Vitro Assay Development - ZipRecruiter : Job Details

Job Description

Capricor Therapeutics is a biotechnology company dedicated to developing transformative therapies for rare diseases, with a primary focus on Duchenne muscular dystrophy (DMD). We are pioneers in cell therapy and exosome-based technology, leveraging our proprietary StealthX platform to engineer innovative treatments. Our team is committed to harnessing cutting-edge science and advanced technologies to meet the unmet needs of patients living with DMD and other challenging medical conditions. Join us on our journey as we push the boundaries of medical science and pave the way for a healthier future.

About the RoleWe are seeking a highly motivated and skilled Scientist/Senior Scientist, Nucleic Acid Delivery and In Vitro Assay Development to join our team. The successful candidate will lead efforts in designing, optimizing, and characterizing nucleic acid delivery platforms for therapeutic applications. This role will involve close collaboration with cross-functional teams in molecular biology, cell biology, and pharmacology.

Key Responsibilities

Nucleic Acid Delivery:

• Develop and optimize protocols for loading nucleic acids (siRNA, PMO, ASO) into delivery vehicles using electroporation or comparable techniques.
• Characterize the loading efficiency, stability, and activity of nucleic acids in delivery vehicles (e.g., exosomes, nanoparticles, or other carriers).

Cell Culture and Molecular Biology:

• Maintain and manipulate primary and immortalized cell lines.
• Design and execute CRISPR-based gene editing experiments.
• Perform transfection, transduction, nucleic acid delivery, and downstream functional assays.

In Vitro Assay Development:

• Design and validate in vitro assays to assess the efficacy and safety of nucleic acid therapeutics.
• Develop and execute PK/PD assays in vitro to characterize therapeutic candidates.

Data Analysis and Reporting:

• Analyze experimental results, interpret data, and present findings to internal and external stakeholders.
• Document experimental protocols and results following standard scientific practices.

Collaboration and Innovation:

• Work collaboratively with cross-functional teams to align experimental designs with project goals.
• Stay up-to-date with advancements in nucleic acid therapeutics, delivery technologies, and in vitro assay development.

Requirements

Minimum Qualifications:

• Ph.D. in Molecular Biology, Biochemistry, Cell Biology, or a related field.
• Hands-on experience with nucleic acid (siRNA, PMO, ASO) loading into delivery vehicles using electroporation or comparable techniques.
• Expertise in cell culture, including maintaining and manipulating various cell lines.
• Demonstrated proficiency in developing and validating in vitro assays.
• Proven experience in PK/PD studies in vitro.

Qualifications:

• Experience with advanced delivery systems (e.g., lipid nanoparticles, exosomes).
• Strong analytical skills and experience with software tools for data analysis (e.g., GraphPad Prism, FlowJo).
• Knowledge of regulatory and safety requirements for therapeutic development.

Soft Skills:

• Excellent organizational and multitasking skills.
• Strong written and verbal communication skills.
• Ability to work independently and in a team-oriented environment.

Compensation (USD)

• Salary Range: $85,000 - $125,000 (commensurate with experience and qualifications).
• Additional benefits include health insurance, retirement plans, and opportunities for professional development.

Location PolicyThis position is based at our headquarters in San Diego, California, with flexibility for occasional remote work as needed.

Come Work With Us!Capricor Therapeutics offers competitive compensation and benefits, generous vacation and parental leave, flexible working hours, and a collaborative work environment.If you're excited about advancing cutting-edge therapies in the biotech industry, we'd love to hear from you!