Senior Scientist/Principal Scientist, In vivo Pharmacology, Discovery Technologies - Eli Lilly and Company : Job Details

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is

Overview:

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

Position Summary:

The Senior Scientist/Principal Scientist in the Discovery Technologies In vivo Pharmacology group will be part of a dynamic group of scientists conducting various research projects to identify large molecule/biologics which can effectively treat various forms of cancer. The candidate will collaborate with discovery teams in NYC, Indianapolis, San Francisco and Louisville for design and execution of studies. The In vivo pharmacology scientist will design and execute experiments and will also be responsible for performing or collaborating in vivo efficacy and PK/PD studies done in preclinical models. Oversight and/or contribution to ADME work during drug development may be required. The in vivo pharmacology scientist will report findings directly to both the oncology scientific and executive leadership and will be a key member of the discovery organization being responsible for maintaining the scientific quality and efficiency of the organization, as well as assist and guide the strategic direction of the company. The candidate is expected to be a dynamic and motivated scientist who can drive experiments and research activities independently, while collaborating extensively with the entire organization to execute various research programs.

Responsibilities:

· Design, execute in vivo studies with pre-clinical discovery and translational biology teams

· Interact and collaborate with various discovery technologies functional teams to develop and implement novel in vivo models

· Prepare drug solutions and inoculations, multiple routes of drug administration (e.g. subcutaneous, tail vein, intraperitoneal, and retro-orbital injection and oral gavage), animal health monitoring, anesthesia, blood samplings, , xenografts, syngeneic mouse models, humanized mouse models

· Perform cardiac, retro-orbital, and facial bleeds, and tumor injections

· Perform tumor measurements using calipers

· Harvest blood, tumor and tissue samples from animals to help establish PK/PD and toxicity measurements, flow cytometry analysis and histology.

· Culture tumor cells according to SOPs and contribute to the development of SOPs

· Stay current on cutting edge technologies and work collaboratively with the in vivo team to validate and implement new in vivo model systems

· Provide scientific expertise on practical implementation of various in vivo applications to support projects across the entire oncology organization

· Work with the entire in vivo team to ensure all instrumentation is properly maintained and calibrated

· Provide scientific expertise when determining organizations to strategically partner with

· Proper documentation and archiving of data and analyses

· Work interactively with project teams and discovery teams to plan and execute experiments as well as be involved in data interpretation and preparation of study reports

· Work interactively with project teams as an in vivo pharmacology expert to ensure appropriate applications and priorities are considered

· Additional roles and responsibilities:

o Communicate results via written and oral presentations at project team meetings, be involved in the coordination and preparation of presentations

o Discuss results with technical as well as non-technical personnel

o Support archiving as well as curating data in internal databases

o Extensive cross functional communication and collaboration with internal and external parties

Basic Requirements:

· BS degree in biological sciences with 5 years of experience or MS in biological sciences with 2-3 years of experience required

· Extensive expertise in: in vivo pharmacology, cell line xenograft establishment, humanized mouse model systems, carrying out preclinical rodent oncology modeling. Experience in IVIS imaging is preferred but not required.

· Proficiency in Graphpad Prism is preferred.

Additional Preferences:

· Diverse experience in cell biology and biochemical techniques to monitor PK/PD relationships

· Experience in drug discovery with regulator reporting

· Proven success working in cross-functional teams in dynamic organizations

· Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business

· Excellent written and verbal communication skills

· Flexibility to adjust priorities over time to meet organizational and scientific goals

· Ability to work independently and as an integral part of a larger collaborative team

· Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines

· Excellent interpersonal, written, and verbal communication skills

· Knowledge and experience documenting and processing in vivo studies

Additional Information:

Physical Demands/Travel:

The physical demands of this job are consistent with a lab environment.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position's work environment is in a Laboratory.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women's Network, Working and Living with Disabilities. Learn more about all of our groups.

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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