Senior Scientist, Protein Engineering - Kelly Science, Engineering, Technology & Telecom : Job Details

Kelly® Science & Clinical is seeking a CMC Project Manager opportunity with a generative AI biotechnology company in Vancouver, WA. If you're passionate about bringing the latest scientific discoveries to life and are ready to take the next step in your career, trust The Experts at Hiring Experts.

Position: Senior Scientist, Protein Engineering

Workplace: Onsite in Vancouver, WA

Salary: $125,000-160,000

Overview

Join our innovative team as a key member within our Protein Engineering and Structural Biology group. In this pivotal role, you will collaborate with Drug Creation and AI teams to spearhead the engineering and optimization of antibodies and multispecific proteins. Your efforts will focus on designing and implementing strategies to enhance the therapeutic efficacy, binding specificity, stability, and manufacturability of our pipeline candidates. Partnering closely with AI, Drug Creation, and Protein Science teams, you'll play a significant role in advancing our cutting-edge platform for binder discovery, protein engineering, and protein production.

Responsibilities:

• Platform Development: Drive the development and optimization of platforms for monoclonal antibodies (mAb) and multispecific therapeutics, covering all stages from design through production, testing, and evaluation.
• Molecule Design: Undertake rational design of molecules by performing structural analyses, recommending changes to improve interactions, specificity, stability, and manufacturability.
• Assay Implementation: Design and conduct binding and biophysical assays to assess the impact of mutations on protein structure and function.
• Collaboration and Coordination: Work closely with Process Development and Analytical Development teams to ensure high-quality protein expression, purification, and characterization.
• Program Leadership: Lead cross-functional programs, act as the representative for Protein Engineering, align and organize efforts across different teams, and ensure project goals are achieved.
• Data Presentation: Regularly summarize and present data to stakeholders, supporting informed decision-making to advance programs.

Qualifications:

• Advanced Degree: PhD in Biochemistry, Structural Biology, Protein Biophysics, or a related field with over 5 years of relevant experience, or MSc with over 8 years focusing on protein engineering, particularly in multispecific therapeutics.
• Expertise and Experience: Proven track record in designing experiments, leading programs, and enabling teams to meet project deadlines.
• Technical Proficiency: Expertise in protein structure-function analyses, computational modeling (e.g., Schrodinger, MOE, Rosetta), and lab-based techniques.
• Innovative Design: Ability to apply structural insights to enhance therapeutic properties, including binding affinity, function, and developability.
• Laboratory Skills: Proficient in protein expression, purification, and quality assessment with familiarity with biophysical characterization techniques (e.g., analytical SEC, DSF, DLS) and binding interaction analyses (e.g., BLI, SPR).
• Leadership and Training: Experienced in training junior scientists and leading cross-functional programs in fast-paced environments.
• Communication: Strong written and verbal communication skills for effectively conveying findings and updates to various teams.
• Core Values Alignment: Demonstrated passion for innovation, teamwork, and a commitment to excellence.

What happens next:

Once you apply, you'll proceed to the next steps if your skills and experience look like a good fit. But don't worry – even if this position doesn't work out, you're still in our network. That means our team of expert Science & Clinical recruiters will have access to your profile, making your opportunities limitless.