Wet Lab R&D Product Development Lead - Base5 Genomics : Job Details

Leading Precision Medicine Into a New Era

Base5 Genomics - spun out of Stanford - is a genomic sequencing biotechnology company developing solutions in immunogenomics to provide best-in-class resolution of the most complex regions of the human genome. The genomics of the immune system is of critical importance for human health and understanding it at an individual level is a critical bridge to personalized medicine we must cross. Base5's innovative solutions are delivering insights into the immunogenomic regions (e.g. HLA, KIR) that will have an immediate and transformative impact on patients' lives.

Base5's founding team has deep technical expertise. Co-Founder and CEO Solomon Endlich has a PhD in theoretical physics from Columbia University but pivoted into molecular biology during his postdoc at Stanford University, where he laid the foundation of Base5 Genomics' proprietary technology in the lab of professor and co-founder Ashby Morrison. Co-Founder and Head of Data Analytics Liza Huijse has a PhD in physics from the University of Amsterdam and held postdoctoral positions at Harvard and Stanford prior to pursuing a career in computational biology. Supported by advisors with critical market insights and investors with expansive industry expertise, Base5 is well positioned to redefine immunogenomics and precision genomics and is currently raising its Series A financing round.

The Role

Base5 Genomics has developed a full stack solution with innovations in areas ranging from high molecular weight DNA targeting and sequencing assays to phasing, assembly and functional analysis pipelines. As its first product, Base5 Genomics delivers fully interpreted, high-resolution sequencing data for entire multi-megabase regions of immunogenomic interest. Base5's platform unlocks the information needed to identify critical genomic biomarkers for precision medicine and discovery, empowering clinicians and researchers in transplant screening, pharmacogenomics, drug and vaccine development, oncology and beyond. As the Wet Lab R&D Product Development Lead, you will be responsible for both strategic as well as technical contributions. You will lead the development of a competitive product portfolio aligned with Base5's short, mid and long term goals. You will also lead the design, execution, and analysis of complex experiments for the development of our first kit + compute product. You will grow and lead a team of highly motivated scientists, which will work in partnership with the compute team to develop new product lines as well as interact directly with customers to provide technical support.

Position Description

• Serve as Product Development lead for molecular biology, assay development, and automation compatibility efforts
• Develop a commercial kit for the high resolution sequencing of complex immunogenomic regions that is scalable and user friendly
• Draft technical product documents, protocols user guides and technical notes
• Implement a continual review process to evaluate opportunities for product enhancements and cost reduction strategies with a focus on enzyme optimization
• Facilitate a collaborative relationship with the compute team to define and refine product requirements for downstream analysis
• Own new product proposals, new product initiation and feasibility study processes
• Manage product plans and drive the stage gate process for product development and commercial release
• Collaborate with the Product Marketing/Business Development teams to generate product roadmaps with technical milestones and deliverables
• Provide commercial support, including the development and delivery of content for technical and sales training

About You

• Passion for biotech product development – you seek out opportunities to develop cutting edge, paradigm shifting product offerings
• Entrepreneurial spirit – you love conceptualizing and bringing together ideas from disparate areas
• Innovative mind – you have a knack for pushing the limits of what we can do today with creative problem solving skills and a desire to create products that are quantum leaps and not just incremental improvements
• Growth mindset – you are a lifelong learner with a desire to expand your skills and those of your team

What You Bring

• PhD. in Genetics, Genomics, Molecular Biology or related scientific field
• Minimum 7 years of experience in research and development and/or technical product management within the life sciences, preferably in genomics technologies, products and/or applications
• Experience in novel genomic assay development required, ideally with long-read platforms and/or high molecular weight DNA
• Deep knowledge of and intuition for the molecular biology associated with DNA and RNA library prep
• Proven success in developing and launching new products
• Experience developing and implementing strategic product development plans
• Automation familiarity is a plus
• Excellent written and verbal communication skills
• Ability to work in a fast paced, dynamic startup environment